The effect of Vitex Agnus castus extract on blood level of prolactin, & compare of its effects on the Lipids level with those of Bromocriptine and Dostinex in women with hyperprolactinemia

Authors
Naiyereh Haerifar 1
Shaker Salari lak 2
1 Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran
2 Department of Public Health, Tabriz Branch, Islamic Azad University, Tabriz, Iran
Abstract
Introduction

Hyperprolactinemia in women results in menstrual disorders, irregular ovulation, amenorrhea, and reduction of progesterone Level after ovulation, due to corpus luteum failure. This study aimed at comparing the effect of Vitagnus fruit extract on blood prolactin level and its effect on altered serum lipids in Hyperprolactinemic women with Bromocriptine and Dustinex.

Materials and Methods

Among the women with Hyperprolactinemia referring to medical Centers, 105 subjects were chosen and classified into 3 groups: Bromocriptin Dustinex and Vitagnus. They were treated during (i.e. 4 cycles), and finally, the blood levels of prolactin, Cholesterol, HDL, LDL, triglycerides were measured.

Results

The results showed that, except in Bromocryptin, in other groups, there was a meaningful difference in each step compared to the earlier step in terms of prolactin level change.

In the Bromocryptin group, after two cycles of treatment, each step showed a meaningful difference from the earlier step (p<0.05). examination of cholesterol levels showed that the reduction of cholesterol levels in various cycles was meaningful. In Dustinex group, there was observed meaningful difference in all steps except the final step of treatment. In the case of Vitagnus, the impact of treatment was meaningful, except in the first step.

The results showed that all drugs had a meaningful effect on LDL level, after the third stage. The increase in serum HDL level for Vitagnus was more than other Tablets in all stages.

Conclusion

Vitagnus decreases the prolactin level meaningfully, Similar to Bromocryptin and Dustinx. Also decreased cholesterol, LDL, and triglyceride, wherever increased HDL level.
Keywords
Vitagnus
Prolactin
Lipids
Bromocriptine
Dostinex
1. S.E. Brown R., C. Kokay I., R. Phillipps H., Hoong Yip S., Gustafson P., Wyatt A., et al,. Conditional Deletion of the Prolactin Receptor Reveals Functional Subpopulations of Dopamine Neurons in the Arcuate Nucleus of the Hypothalamus.The Journal of Neuroscience.2016; 36(35):9173-9185
2. Saleem M., Martin H., Penelope Coates P.. Prolactin Biology and Laboratory Measurement: An Update on Physiology and Current Analytical Issues. Clin Biochem Rev. 2018 Feb; 39(1): 3-16.
3. Alhag Gurashi R., Elsadig Hummeida M., Galal Abdelaziz F. Diagnostic Value of Serum Prolactin in Ovarian Cancer. Int. Biol. Biomed. J. Autumn 2018; Vol 4, No 4.
4. Speroff L., Fritz M. A. Clinical Gynecologic Endocrinology and Infertility. Lippincott Williams & Wilkins, pp. (2005).
5. Gómez R., Abad A., Delgado F., Tamarit S., Simón C., Pellicer A. Effects of Hyperprolactinemia Treatment with the Dopamine Agonist Quinagolide on Endometriotic Lesions in Patients with Endometriosis-Associated Hyperprolactinemia. Fertility and Sterility, 2011; 95: pp 882-888. e881.
6. Webster J., Piscitelli G., Polli A., Ferrari C. I., Ismail I. Scanlon, M. F. A Comparison of Cabergoline and Bromocriptine in the Treatment of Hyperprolactinemic Amenorrhea. New England Journal of Medicine, 1994; 331: pp 904-909.
7. Boianov M., Vezenkova L. Khristov V. Suppression of Hyperprolactinemia in Pituitary Microadenoma with Cabergoline (Dostinex). Akusherstvo i ginekologiia, 2005; 44: pp 34-38.
8. Berger D., Schaffner W., Schrader E., Meier B., Brattström, A. Efficacy of Vitex Agnus Castus L. Extract Ze 440 in Patients with Pre-Menstrual Syndrome (Pms). Archives of gynecology and obstetrics. 2000; 264: pp 150-153.
9. Liu J., Burdette J., Sun Y., Deng S., Schlecht S., Zheng, W., et al. Isolation of Linoleic Acid as an Estrogenic Compound from the Fruits of Vitex Agnus-Castusl. (Chaste-Berry). Phytomedicine. 2004; 11: pp 18-23.
10. Shahnazi M., Khalili A. F., Hamdi K., Ghahremaninasab, P. The Effects of Combined Low-Dose Oral Contraceptives and Vitex Agnus on the Improvement of Clinical and Paraclinical Parameters of Polycystic Ovarian Syndrome: A Triple-Blind, Randomized, Controlled Clinical Trial. Iranian Red Crescent Medical Journal. 2016; 18: pp.
11. Jarry H., Leonhardt S., Gorkow C, Wuttke W. In Vitro Prolactin but Not LH and FSH Release Is Inhibited by Compounds in Extracts of Agnus Castus: Direct Evidence for a Dopaminergic Principle by the Dopamine Receptor Assay. Experimental and Clinical Endocrinology & Diabetes. (1994); 102(06): 448-454.
12. Milewicz A., Gejdel E., Sworen H., Sienkiewicz K., Jedrzejak J., Teucher T., et al. Vitex Agnus Castus Extract in the Treatment of Luteal Phase Defects Due to Latent Hyperprolactinaemia I Results of a Randomized Placebo-Controlled Double Blind Study. Arzneimittel Forschung. 1993; 43: G 752-G 752.
13. Samuel T., Okonkwo C., Ezeazuka S., Ekpoiba, A. Endocrinological and Metabolic Effects of a Polyherbal Decoction of Five Nigerian Folkloric Herbs on Haloperidol Induced Hyperprolactinemia. Journal of Pharmacognosy and. 2013; 5(6): 114-119.
14. Wuttke W., Jarry H., Christoffel V., Spengler B. Seidlova-Wuttke, DChaste Tree (Vitex Agnus-Castus)–Pharmacology and Clinical Indications. Phytomedicine. 2003; 10: pp 348-357.
15. Haider A., Spellman C., Mok M. PROLACTIN-SECRETING MICROADENOMA MASKED BY A HERBAL PRODUCT, VITEX AGNUS-CASTUSAACE CLINICAL CASE REPORTS. 2017; Vol 3 No. 1 Winter e51.
16. Christie S., Walker A. F. Vitex Agnus-Castus L.: (1) a Review of Its Traditional and Modern Therapeutic Use ;( 2) Current Use from a Survey of Practitioners. Eur J Herbal Med. 1997; 3: pp 29-45.
17. Dugoua J.-J., Seely D., Perri D., Koren G., Mills, E. Safety and Efficacy of Chastetree (Vitex Agnus-Castus) During Pregnancy and Lactation. Can J Clin Pharmacol. 2008; 15(1): e74-e79.
18. Daniele C., Coon J. T., Pittler M. H., Ernst, E. Vitex Agnus Castus. Drug Safety.2005; 28(4): 319-332.
19. Lucks B. C. Vitex Agnus Castus Essential Oil and Menopausal Balance: A Research Update. International Journal of Aromatherapy. 2003; 13: pp 169-172.
20. Melmed S., Casanueva F. F., Hoffman A. R., Kleinberg D. L., Montori V. M., Schlechte J. A., et al. Diagnosis and Treatment of Hyperprolactinemia: An Endocrine Society Clinical Practice Guideline. The Journal of Clinical Endocrinology & Metabolism. 2011 ;( 2)96; 273-288.
21. Tabak J., Toporikova N., Freeman M. E., Bertram, R. Low Dose of Dopamine May Stimulate Prolactin Secretion by Increasing Fast Potassium Currents. Journal of computational neuroscience. (2007); 22(2): 211-222.
22. Ginat D. T. Bromocriptine (Parlodel) and Cabergoline (Dostinex). Neuroimaging Pharmacopoeia, 2015; Springer: 189-196.
23. Hu Y., Xin H.-L., Zhang Q.-Y., Zheng H.-C., Rahman K., Qin L.-P. Anti-Nociceptive and Anti-Hyperprolactinemia Activities of Fructus Viticis and Its Effective Fractions and Chemical Constituents. Phytomedicine.2007; 14(10): 668-674.
24. Ye Q., Zhang Q.-Y., Zheng C.-J., Wang Y., Qin L.-P. Casticin, a Flavonoid Isolated from Vitex Rotundifolia, Inhibits Prolactin Release in Vivo and in Vitro. Acta Pharmacologica Sinica.2010; 31(12); 15: 1564.
25. Diab A. E.-a. A., Elsayed Z. I., Zahra M. H., Shalaby A. A., Mohamed E. F. Biological Study of the Extract of Some Species of Vitex Agnus-Castus (Kafmurium) Grown in Egypt, IJPSR. 2015;