شیوع شاخصهای سرمی عفونت هپاتیت B و عوامل خطر مرتبط با آن در زنان باردار مراجعه کننده به آزمایشگاه تشخیص طبی جهاد دانشگاهی در نیشابور سال 1393

نویسندگان
محمد رضا هدایتی مقدم
محمد صالحی
علی اکبر مرادیان ایوری
چکیده
مقدمه

انتقال از مادر به جنین، از راه‌‌های شایع انتقال ویروس هپاتیت B(HBV) است. این میزان در صورت مثبت بودن مادر از نظر آنتی‌ژن پوششی هپاتیت B(HBeAg) بیش از 90 درصد است. مطالعه حاضر با هدف بررسی شاخص‌های سرمی عفونت ویروس هپاتیت B در زنان باردار مراجعه کننده به آزمایشگاه تشخیص طبی جهاد دانشگاهی خراسان رضوی در شهرستان نیشابور انجام شد.

مواد و روش‌‌ها

در این مطالعه توصیفی-تحلیلی از 1283 زن بارداری که طی تیر ماه تا بهمن ماه سال 1393 جهت انجام آزمایش‌‌های روزمره دوران بارداری به آزمایشگاه مراجعه نموده بودند نمونه سرم تهیه گردید و با روش الایزا از نظر آنتی‌ژن سطحی هپاتیت B (HBsAg) بررسی گردید. برای نمونه‌‌های HBsAg مثبت، سطح سرمی آنتی‌بادی علیه آنتی‌ژن هسته هپاتیت B (HBcAb)، آنتی‌ژن پوششی هپاتیت B (HBeAg) و آنتی‌بادی ضد آن (HBeAb) با استفاده از روش الایزا بررسی شد. داده‌ها توسط SPSS v.18 آنالیز شدند.

یافته‌‌ها

1/09 درصد از زنان باردار HBsAg مثبت بودند. HBcAb توتال در نمونه سرم همه زنان مبتلا به هپاتیت B، مثبت بود اما HBcAb از نوع IgM تنها در 2 نفر (14/3 درصد) شناسایی شد. همچنین نتیجه آزمایشات ابتلا به HBeAg و HBeAb به ‌ترتیب در 2 نفر (14/3 درصد) و 9 نفر (64/3 درصد) از این زنان مثبت گزارش شد.

نتیجه‌‌گیری

شیوع ویروس هپاتیت B در زنان باردار نیشابور کمتر از شیوع آن در جمعیت عمومی شهر مشهد، مرکز استان خراسان رضوی و جمعیت عمومی کل کشور می‌باشد.
کلیدواژه‌ها
ویروس هپاتیت B(HBV)
شیوع
زنان باردار
ایران

عنوان مقاله English

Prevalence of Serological Markers of Hepatitis B Virus Infection and Its Related Risk Factors in Pregnant Women Referred to the Medical Diagnostic Laboratory of ACECR in Neyshabur, during 2014-2015

نویسندگان English

Mohammad Reza Hedayati Moghaddam
Mohammad Salehi
Ali Akbar Moradian Eivary
چکیده English

Introduction

Mother to child transmission is one of the most common modes of hepatitis B virus (HBV) infection. The risk of transmission will be as high as 90% if a seroactivity for HBeAg find in the mother. This cross-sectional study aimed to assess the prevalence of HBV serological markers in pregnant women referred to the Medical Diagnostic Laboratory of ACECR in Neyshabur, northeast of Iran.

Materials and Methods

From June 2014 to February 2015, the all pregnant women who referred for evaluation of HBV infection (n=1283) were enrolled. The serum samples were evaluated for HBsAg by ELISA test and further analyzed to detect other markers of the infection, including HBeAg, HBeAb, total HBcAb, and IgM HBcAb.

Results

HBsAg found in 1.09% (14/1283) of the participants. The total HBcAb test was positive in all cases; however, the IgM anti-HBc was positive in only two (14.3%) cases. Seropositivity for HBeAg and HBeAb were reported in 2 (14.3%) and 9 (64.28%) participants, respectively.

Conclusion

The prevalence of HBV infection in pregnant women in Neyshabur was lower than that in general population of Mashhad, capital city of Razavi Khorasan province, and general population of the whole of the country.

کلیدواژه‌ها English

Hepatitis B Virus (HBV)
seroprevalence
Pregnant Women
Iran
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