Effect of 8 weeks aerobic training with cinnamon extract on retinol binding protein 4 (RBP4) and insulin resistance in rats fed with high-fructose

Authors
Ahmad Abdi
Parvin Farzanegi
Hajar Abaszade
Malek Habibi
Islamic Azad University
Abstract
Introduction

RBP4 is an adipokine that participates in insulin function and glucose metabolism. The elevated RBP4 serum levels were previously described in insulin-resistance states. The aim of the present study was to investigate the effect of 8 weeks aerobic training and hydroalcoholic cinnamon extract on RBP4 and insulin resistance in rats fed with high-fructose.

Materials and Methods

In this experimental study thirty-six Wistar male rats were randomly divided into the four groups: control (n=9), training (n=9), cinnamon (n=9), and training–cinnamon (n=9). Insulin-resistance status induced by %10 fructose solutions during 5 weeks. Training groups subjected to a three-day per week aerobic training program for 8 weeks. The extract groups were fed 200 ml/kg/day cinnamon extract. The data were analyzed using one-way ANOVA and level of statistical significance was set at P<0.05.

Results

The results showed that aerobic training with or without the extract significantly decreased serum RBP4 (p<0.001). Also, in all the experimental groups significant decrease in serum insulin, glucose, and HOMA-IR, was observed (p=0.005, p=0.008 and p=0.001, respectively).

Conclusion

Based on the findings, aerobic exercises has beneficial effects on serum RBP4. It seems that the cinnamon extract has no effect on amelioration of insulin resistance through RBP4.
Keywords
Aerobic Exercise
Cinnamon Extract
RBP4
Insulin Resistance
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