The effect of silver nanoparticle toxicity on the inflammatory markers of heart tissue following an anaerobic training course in male wistar rats

Authors
forogh javaheri hoshi 1
asieh abbassi daloii 1
seyed javad ziaolhagh 2
1 Department of Exercise Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran.
2 Department of Exercise Physiology, Shahrood Branch, Islamic Azad University, Shahrood, Iran
Abstract
Exposure to nanoparticles toxicity leads to impairment of heart function and increases inflammatory cytokines. The purpose of this study was to investigate the effect of silver nanoparticle toxicity on the inflammatory markers of heart tissue following an anaerobic training course in male wistar rats.

Materials and Methods

In this experimental study, 30 male Wistar rats aged 8 to 12 weeks and weighing 202±34.9 gr were randomly divided into 6 groups include of control, anaerobic training, anaerobic training - nano biological, anaerobic training - nanochemical, nano-biological and nanochemical. Chemical and biological silver was injected intraperitoneally after a period of anaerobic training. The specimens were discarded after 48 hours, and the heart tissue was removed.

Results

The results showed that ICAM, hsCRP, IL-8 and IL-6 levels of male Wistar rats were different in groups (P=0.000). The hsCRP concentration of heart tissue was significantly lower in the Nanochemical - anaerobic and Nanobiological - anaerobic training group compared to Nanochemical and Nanobiological groups respectively (P=0.000). Also, IL-8 of heart tissue was significantly lower in the Nanochemical - anaerobic group compared to the Nanochemical group (P=0.000).

Conclusion

The toxicity of silver nanoparticles was associated with an increase in inflammatory markers in the heart tissue. It seems regular anaerobic training may have a protective effect against the increase some of the inflammatory factors due to the toxicity of chemical and biological silver nanoparticles.
Keywords
Silver nanoparticles
Exercise
Inflammatory parameters
Heart Tissue
Rats
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Journal of Netshabur University of Medical Sciences
Volume 7, Issue 3 - Serial Number 24
Summer 2019
Pages 131-142