Effect of 8 week continuous training with resveratrol supplementation on anti-oxidative markers (SOD and GPX) and oxidative marker (MDA) of hepatocyte tissue in streptozotocin-diabetic male rats

1. American Diabetes Association, Diagnosis and classification of diabetes mellitus, Diabetes Care. 2010; 33(l1): 62–69.
2. Maritim AC, Sandres RA. Watkins, Diabetes, oxidative stress, and antioxidants: a review, J. Biochem. Mol. Toxicol. 17 (2003) 24e39.
3. Stevens PS. Redox-based mechanisms in diabetes, Antioxid. Redox Signal. 7(2005) 1483e1485.
4. Gill PS, Wilcox CS. NADPH oxidases in the kidney, Antioxid. Redox Signal. 8(2006) 1597e1607.
5. Ochsendorf FR. Infections in the male genital tract and reactive oxygen species. Hum Reprod Update. 1999; 5:45.
6 .Hamden K, Carreau S, Jamoussi K, Miladi S, Lajmi S, Aloulou D, et al. 1,25 Dihydroxyvitamin D3: Therapeutic and Preventive Effects against Oxidative Stress, Hepatic, Pancreatic and Renal Injury in Alloxan- Induced Diabetes in Rats. J Nutr Sci Vitaminol. 2009, 55 (3), 215-222.
7.Winterbourn CC, Munday R. Glutathione-mediated redox cycling of alloxan. Mechanisms of superoxide dismutase inhibition and of metal-catalyzed OH. formation. BiochemPharmacol 1989, 38, 271-277.
8. Lenzen S, Panten U. Alloxan: history and mechanism of action. Diabetologia1998, 31, 337-342.
9. Sakurai K, Ogiso T. Inhibitory effect of glutathione on the generation of hydroxyl radicals in the reaction system of glutathione-alloxan.Chem Pharm Bull 1991, 39, 737-742.
10. Ji LL. 1999. Antioxidants and oxidative stress in exercise. Experimental Biology and medicine. 222(3):283-92.
11. Dehbashi Behbahani G, Hajhosseini R, Hoghoughirad L, Hedayati M. 2010. Sensitive chemiluminescence method for superoxide dismutase activity assaye. Kowsar Medical Journal. 15(3):129-33.(Persian)
12. Mc Bride JM, Kraemer WJ. 1999. Free radicals, exercise and antioxidants. Med Sci Sports Exerc; 83-175: (2) 13.
13. Radak Z, Inoue A, Kizakit M, Ishis OH, Susuki K, Chin T, Noh O. 1995. Superoxide dismutase reduces oxidative damage in skeletal muscle of rats during exhaustive exercise. JAPPL Physiol; 79: 129-35.
14. Gaeini A, Sheykh Aleslami VD, Alameh A, Ravasi A, Kordi M, Mogharnasi M. 2008. Effect of enduring training and a detraining period on lipid peroxidation and antioxidant system in wistar rats. Journal of Movement Science. 6(11):51-63.(Persian)
15 .Ahmadi Kani Gholzar. Farhad, SheikholeslamiVatani. Dariush, mojtahedi. Hossein, Marandi. Seyed Mohammad, Mashhadi. Masud. 1390."The role of resistance training and protein supplement's antioxidant status in overweight young men." Biological Sciences sport11. Pp. 103-121. (Persian)
16. Mooren FC, Blöming D, Lechtermann A, Lerch MM, Volker K. Lymphocyte apoptosis after exhaustive and moderate exercise. J Appl Physiol. 2002, 93, 147–153.
16 .Subramanian SP, Bhuvaneshwari S, Prasath GS. Antidiabetic and antioxidant potentials of Euphorbia hirta leaves extract studied in streptozotocin-induced experimental diabetes in rats. Gen Physiol Biophys 2011, 30(3), 278-85.
17. Hunter GR, Wetzstein CJ, Fields DA, Brown A, & Bamman M. Resistance training increases total energy expenditure and free-living physical activity in olderadults. J Appl Physiol. 2000, 89, 977–984.
18. Corder R, Warburton R. C, Khan N. Q. The resvratrol-induced pseudo laminar shear stress response: a new concept for the reversal of endothelial dysfunction. Clin Sci (Lond) 2004, 107(5), 513-7.
19. Smoliga J. M, Baur J. A, Hausenblas H. A. Resveratrol and health--a comprehensive review of human clinical trials. Mol Nutr Food Res 2011, 55(8), 1129-1141.
20 .Bagchi D, Sen C. K, Ray S.D. Molecular mechanisms of cardioprotection by a novel resvratrol. Mutat Res, 2003, 524, 87-97.
21. Matsuhisa S, Otani H, Okazaki T, Yamashita K, Akita Y, Sato D, Moriguchi A, Imamura H,Iwasaka T, Angiotensin iitype 1 receptor blocker preserves tolerance to ischemia-reperfusion injury in dahl saltsensitive rat heart. Am J Physiol Heart Circ Physiol. 2008, 294, 2473-2479.
22. Sharma, S., Misra, C.S., Arumugam, SAntidiabetic activity of resveratrol, a known SIRT1 activator in a genetic model for type-2 diabetes. Phytother. Res. In press. 2011 Jan; 25(1):67-73.
23. Su, H.C., Hung, L.M. Cheng, J.K Resveratrol, a red wine antioxidant, possesses an insulin-like effect in streptozotocin-induced diabetic rats. Am. J. Physiol. Endocrinol. Metab. 2006;290: 1339–1346.
24. Bezzerides V, Rosenzweig A, Saying yes to exercise and NO to cardiac injury. Circ Res 108 (2011) 1414-1416.
25. Tartibian B, Baghaei B, Baradaran B. Catalase Enzyme Gene Expression and Oxidant Markers’ Levels in Trained Women: Effect of Incremental Exercise. The Journal of Shahid Sadoughi University of Medical Sciences. 2013;20(6):778-88. (Persian)
26. Azamian Jazi A, Shokouhi R. The Effect of an Eight Week Combined Exercise Training on Oxidative Stress and Lipid Peroxidation in Postmenopausal Women with Type 2 Diabetes. JSSU. 2016; 24 (8):667-678. (Persian)
27. Zolfalipor M; Farzanegi P; Habibian M. Combined Effect of Swimming Training and Arbutin Supplementation on Kidney Total Oxidant and Antioxidant Status in Alloxan-induced Diabetic Rats. 2016; 18(2): 85-95. (Persian)
28. Hovanloo F, Hedayati M, Ebrahimi M, Abednazari H. Effect of various time courses of endurance training on alterations of antioxidant enzymes activity in rat liver tissue. Pejouhesh. 2011; 35 (1) :14-19.(inpersian).
29. Azad MarjaniK,Didani Z, Kargarfar M. The Effects of Vitamin Supplementation on Oxidative Stress Indices after Anaerobic Activity in Water Polo Players. Academic Journal. 2012;30(199):p1.
30. ModiriM,Daryanoosh F, Tanideh N, Mohammadi M, Firoozmand H. The Effects Of Short And Middle Times Aerobic Exercise With High Intensities On Ingredients Antioxidant In Female SpragueDawley Rats. Medical JournalOf Mashhad University Of Medical Science. 2014;57(3):587-95. (Persian)
31. Moeini Fard, M, Hedayati, M. Alloxan and streptozotocin, diabetes research tool. Applied Sport Physiology Research1393;10(20):13-22. (Persian)
32. Melissa A. Linden, Justin A. Fletcher, E. Matthew Morris, Grace M. Meers, M. Harold Laughlin, Frank W. Booth, James R. Sowers, Jamal A. Ibdah, John P. Thyfault1, Scott Rector R. Treating NAFLD in OLETF Rats with Vigorous-Intensity Interval Exercise Training Med Sci Sports Exerc. 2015; 47(3): 556–567.
33. Shankar S, Singh G, Srivastava RK. Chemoprevention by resveratrol: molecular mechanisms and therapeutic potential. Front Biosci 2007, 12, 4839–54.
34. Kumar G, Sharmila Banu G, Ganesan Murugesan A. Effect of Helicteres isora bark extracts on heart antioxidant status and lipid peroxidation in streptozotocin diabetic rats. J Appl Biomed. 2008;6: 89-95.
35. Formagio AS, Kassuya CA, Neto FF, Volobuff CR, Iriguchi EK, Vieira Mdo C, et al. The flavonoid content and antiproliferative, hypoglycaemic, anti-inflammatory and free radical scavenging activities of Annona dioica St. Hill. BMC Complement Altern Med. 2013 Jan; 13: 14. doi: 10.1186/1472-
6882-13-14.
36. Jeong SM, Kang MJ, Choi HN, Kim JH, Kim JI. Quercetin ameliorates hyperglycemia and dyslipidemia and improves antioxidant status in type 2 diabetic db/db mice. Nutr Res Pract. 2012 Jun; 6(3): 201-7. doi:10.4162/nrp.2012.6.3.201.
37. Dekleva M, Lazic JS, Pavlovic-Kleut M, Mazic S, Stevanovic A, Soldatovic I, et al. Cardiopulmonary exercise testing and its relation to oxidative stress in patients with hypertension. Hypertens Res. 2012;35(12):1145-51.
38. Shin YA, Lee JH, Song W, Jun TW. Exercise training improves the antioxidant enzyme activity with no changes of telomere length. Mech Ageing Dev. 2008;129(5):254-
39. Vincent HK, Powers SK, Stewart DJ, Demirel HA, Shanely RA, Natio H. Short term exercise training improves diaphragm antioxidant capacity and endurance. Eur J Appl Physiol 2000; 81: 67-74.
40. Alipour M, Salehi I. Effect of exercise on diabetes-induced oxidative stress in the rat hippocampus. Iranian Red Crescent Medical Journal. 2012; 14(4): 222–228. (Persian)
41. Pereira AdS, Spagnol AR, Luciano E, Leme JACdA. Influence of aerobic exercise training on serum markers of oxidative stress in diabetic rats. Journal of Physical Education. 2016;27(3):20-9.
42. Korb A, Cechinel LR, Bertoldi K, Delevatti RS, Meireles LCFd, Moysés FdS, et al. Effects of acute exercise and periodised training performed in different environments on oxidative status parameters in patients with type 2 diabetes. Anais. 2015;1(12):1-10.
43. Ghahremani Moghaddam M, Hejazi K. Effect of aerobic training on Endothelin-1 and Malondialdehyde in inactive elderly women. Journal of Gorgan University of Medical Sciences. 2016;18(3):52-7. (Persian)
44. Tremellen K. Oxidative stress and male infertility, a clinical perspective. Hum Reprod Update. 2008; 14: 243-280.
45. Ascensão A, Ferreira R, Magalhães J. Exercise-induced cardioprotection--biochemical, morphological and functional evidence in whole tissue and isolated mitochondria. Int J Cardiol. 2007 Apr; 117(1):16-30.
46. Bhattacharya A, Chatterjee A, Ghosal S, Bhattacharya SK. Antioxidant activity of active tannoid principles of Emblica officinalis (amla). Indian J Exp Biol. 1999 Jul;37(7):676-80.
47- Subramanian SP, Bhuvaneshwari S, Prasath GS. Antidiabetic and antioxidant potentials of Euphorbia hirta leaves extract studied in streptozotocin-induced experimental diabetes in rats. Gen Physiol Biophys 2011, 30(3), 278-85
48. Wu RE, Huang WC, Liao CC, Chang YK, Kan NW, Huang CC, Resveratrol protects against physical fatigue and improves exercise performance in mice. Molecules 2013; 18(4): 4689-702.
49. Wang ZM, Chen YC, Wang DP. Resveratrol, a natural antioxidant, protects monosodium iodoacetate-induced osteoarthritic pain in rats. Biomed Pharmacother 2016; 83: 763-70.
50. Gómez-Zorita S, Fernández-Quintela A, MacArulla MT, Aguirre L, Hijona E, Bujanda L, et al. Resveratrol attenuates steatosis in obese Zucker rats by decreasing fatty acid availability and reducing oxidative stress. British Journal of Nutrition. 2012;107(2):202-10.
51.Wang H, Jiang T, Li W, Gao N, Zhang T. Resveratrol attenuates oxidative damage through activating mitophagy
in an in vitro model of Alzheimer's disease. Toxicol Lett 2018;282:100-8.
52. Elbe H, Gul M, Cetin A, Taslidere E, Ozyalin F, Turkoz Y, et al .Resveratrol reduces light and electron microscopic changes in acetaminophen-induced hepatotoxicity in rats: Role of iNOS expression. Ultrastruct Pathol
2018:42(1):39-48.
53. Asgari S, Emami A, Shams Ardakani M, Naderi Gh, et al. Examine the effect of antioxidants, essential fruit and branches Junipperusexcelca subsp excelsa on oxidative systems. J Med Plants. 2007; 23: 59-60. (Persian)
54. Rahzani K, Malaki Rad A, Shariat Zade SM, Beirami M, et al. Compare the effect of aqueous extract and wheat germ oil on oxidative stress in male rat blood. J Med Plants. 2009; 5: 19-24.
55. Inoue H, Kishimoto A, Ushikoshi-Nakayama R, Hasaka A, Takahashi A, Ryo K, et al. Resveratrol improves salivary dysfunction in a non-obese diabetic (NOD) mouse model of Sjogren's syndrome. J Clin Biochem Nutr 2016; 59(2): 107-12.
56. Farzanegi P, Mahdian H, Farzaneh-Hesari A, The effect of combined therapy with resveratrol, and continuous and interval exercises on levels of apoptotic biomarkers in heart tissue of male rats with non-alcoholic fatty liver. Feyz, Journal of Kashan University of Medical Sciences, December, 2018; Vol. 22, No 5, Pages 469-477.(Persian)
57. Tofighi A, Ebrahimi Kalan A, Jamali Qarakhanlou BJ. The effect of resveratrol supplementation and aerobic training on cardiac tissue alteration of rats with acute myocardial infarction. Iran J Physiol Pharmacol 2017; 1: 211-21 .(Persian)
58.Hajighasem A, Farzanegi P, Mazaheri Z. Effects of combined therapy with resveratrol, continuous and interval exercises on apoptosis, oxidative stress, and inflammatory biomarkers in the liver of old rats with non-alcoholic fatty liver disease. Arch Physiol Biochem 2018; 20: 1-8. (Persian)
59. Tung BT, Rodriguez-Bies E, Ballesteros- Simarro M, Motilva V, Navas P, Lopez-Lluch G. Modulation of endogenous antioxidant activity by resveratrol and exercise in mouse liver is age dependent. J Gerontol A Biol Sci Med Sci 2014; 69(4): 398-409.
60. Fakoori Jouibari M, Farzanegi P, Barari A. The effect of 8-week aerobic exercise with purslane supplementation consumption on peroxidant and antioxidants indicators in women with type 2 diabetes. SSU_Journals. 2014;22(1):928-39. (Persian)