Effect of 10 weeks moderate aerobic training on betatrophin and irisin levels in obese Wistar rats Title

Authors
abbas saremi
mohammad parastesh
Department of Exercise Physiology, Faculty of Sport Sciences, Arak University, Arak, Iran
Abstract
Introduction

Betatrophin and irisin are liver and muscle tissue produced proteins that regulate triglyceride metabolism as well as glucose homeostasis. This study was designed to evaluate the levels of betatrophin and irisin in obese rats before and after 10 weeks of aerobic training.

Materials and Methods

Twenty four, 8-week-old male Wistar rats (249.8±11.2g) were selected and purchased for the research. After obesity induction by a high-fat diet, the animals were randomly divided into two groups: aerobic training (n = 12) and control (n = 12). Also, a matched group with normal weight was selected for baseline comparisons. The animals trained 60 min/day, 5 days/week for 10 weeks. Bodyweight, lipid and glycemic profiles, and betatrophin and irisin levels were assessed after 10 weeks of aerobic training. The data were compared using analysis of variance (P<0.05).

Results

Results showed that weight mass (P<0.01), plasma total cholesterol (P<0.02), triglyceride (P<0.05), and fasting glucose (P<0.04) were reduced in obese rats following the aerobic training. Plasma betatrophin was significantly reduced in aerobic training compared to control groups (P<0.02). Conversely, irisin concentration was significantly elevated with aerobic training (P<0.03).

Conclusion

The data demonstrated that moderate-intensity aerobic training prevented obesity-induced cardiovascular disorders simultaneously with improvements in betatrophin and irisin levels in obese rats.
Keywords
Aerobic Exercise
betatrophin
metabolic syndrome
Irisin
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Journal of Netshabur University of Medical Sciences
Volume 8, Issue 1 - Serial Number 26
Winter 2020
Pages 115-126