Antidepressant effects of hydroalcoholic extract of Malva sylvestris leaves using mice model of depression induced by reserpine

Authors
Rahmatollah Parandin
Kiomars Armand torab
Department of Biology, Faculty of Sciences, Payame Noor University, Tehran, Iran
Abstract
Introduction

Malva sylvestris is a symbol of calmness and has antioxidant and radical scavenging properties. The objective of this study was to investigate the antidepressant effects of hydroalcoholic extract of Malva sylvestris leaves in mice using forced swim and tail suspension tests.

Materials and Methods

In this experimental study, 42 male mice were distributed in 6 groups (n=7), including vehicle (normal saline), negative control (reserpine), fluoxetine (positive control), and three groups treated with hydroalcoholic extract of Malva sylvestris (150, 300 or 450 mg/kg, i.p.). Forced swim and tail suspension behavioral tests were used to measure depression in mice. Antioxidant capacity and malondialdehyde (MDA) content in brain of mice were determined.

Results

Reserpine treatment significantly increased the time of immobility in behavioral tests. Fluoxetine and extract in all three doses in the Forced swim (P<0.001) and at 300 (P<0.01) and 450 mg/kg (P<0.001) doses reduced the immobility time. Reserpine significantly increased the MDA level and decreased the antioxidant capacity of brain. Fluoxetine and extract at 300 and 450 mg/kg doses increased antioxidant capacity and reduced the MDA level of brain.

Conclusion

The results of this study suggest that Malva sylvestris leaves have an antidepressant-like activity similar to fluoxetine which may be mediated by its antioxidant and radical scavenging components.
Keywords
antidepressant
forced swimming test
mice
reserpine
Malva sylvestris
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Journal of Netshabur University of Medical Sciences
Volume 8, Issue 1 - Serial Number 26
Winter 2020
Pages 137-149