اثر دو نوع تمرین بازتوانی تداومی و تناوبی بر VEGF و اندوستاتین سرمی در مردان مبتلا به بیماری قلبی پس از عمل آنژیوپلاستی عروق کرونر (PCI)

نویسندگان
بهمن میرزایی
فرهاد شیری
گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه گیلان، ایران
چکیده
مقدمه

آنژیوژنز فرایندی حیاتی در رشد و توسعۀ بافتی به ویژه بافت عضلانی محسوب می‌شود که تحت تأثیر انقباض عضلانی قرار می­گیرد. توسعه فرآیند آنژیوژنز در بیماران قلبی بسیار حیات بخش است. از این رو هدف پژوهش حاضر بررسی تاثیر دو نوع تمرین بازتوانی قلبی تداومی و تناوبی بر VEGF و اندوستاتین سرمی در بیماران مردان مبتلا به بیماری قلبی پس از عمل آنژیوپلاستی عروق کرونر (PCI) بود.

مواد و روش‌­ها

تعداد 30 نفر از بیماران واجدین شرایط به صورت تصادفی در سه گروه تمرین هوازی، تناوبی و کنترل قرار گرفتند. دو گروه تمرینی با توجه به پروتکل اختصاصی خود به مدت هشت هفته به تمرین پرداختند. 48 ساعت قبل و بعد از آخرین جلسۀ تمرینی در شرایط ناشتا، خون­گیری از گروه­های پژوهش انجام شد. مقادیر VEGF و ESبا استفاده از کیت به روش ELISA اندازه­گیری شد. برای تحلیل داده­ها از آزمون تحلیل واریانس با اندازه‌گیری مکرر و در صورت وجود تفاوت بین گروه­ها برای تعیین محل تفاوت، از آزمون تعقیبی بونفرونی استفاده شد.

یافته­‌ها

نتایج پژوهش حاضر نشان داد که اجرای تمرینات تداومی و تناوبی باعث افزایش معنی‌داری در مقدار VEGFو کاهش مقدار اندوستاتین نسبت به گروه کنترل گردید. کاهش اندوستاتین در گروه تمرین تناوبی پررنگ‌تر بود.

نتیجه­‌گیری

تمرین تناوبی می‌تواند مانند تمرین هوازی، به عنوان تمرینی ایمن و اثربخش در دوره بازتوانی قلبی مورد استفاده قرار گیرد. حتی می‌توان نتیجه گرفت که تمرین تناوبی در کاهش مسیر مهاری آنژیوژنز اثر بخشی بیشتری داشت.
کلیدواژه‌ها
هایپوکسی
بازتوانی قلبی
اندوتلیال
تنش برشی

عنوان مقاله English

The effect of two types of continuous and interval cardiac rehabilitation on serum VEGF and endostatin in Male cardiac patients after coronary angioplasty (PCI)

نویسندگان English

bahman mirzaei
farhad shiri
Department of Exercise physiology, Faculty of Exercise Science, university of Guilan, Guilan, Iran
چکیده English

Introduction

Angiogenesis is a critical process in tissue growth and development, especially in muscle tissue that is affected by muscle contraction. The development of the angiogenesis process in cardiac patients is crucial. For this the aim of this study was to investigate the effect of two types of continuous and interval cardiac rehabilitation training program on serum VEGF and Endostatine after coronary angioplasty (PCI) in Male cardiac patients.

Materials and Methods

Thirty patients were randomly divided into three (aerobic, interval and control) groups. Two training groups trained for eight weeks according to their own protocol. Fasting blood sample was taken from the groups 48 hours before and after the training protocol. Serum VEGF and ES were measured by ELISA kit. To analyze the data, repeated measures ANOVA test was used and when differences was significant Bonferroni post hoc test was used to define the place of deference.

Results

The results of this study showed that performing continuous and interval training increased VEGF level and decreased Endostatin significantly compared to the control group. Endostatin decline was more pronounced in the interval exercise training group.

Conclusion

Interval training can be used as a safe and effective method during cardiac rehabilitation like aerobic training method. It can even be concluded that interval exercise was more effective in reducing the inhibitory pathway of angiogenesis.

کلیدواژه‌ها English

Hypoxia
Cardiac Rehabilitation
Endothelial
Shear Stress
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