تاثیر 8 هفته تمرین هوازی و مکمل دهی ویتامین D بر شاخص‌های گلاسمیک در زنان یائسه مبتلا سندرم متابولیک

نویسندگان
1 گروه تربیت بدنی، واحد سنندج، دانشگاه آزاد اسلامی، سنندج، ایران
2 گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه رازی، کرمانشاه، ایران
3 گروه تربیت بدنی، واحد سقز، دانشگاه آزاد اسلامی، سنندج، ایران
چکیده
مقدمه: سندرم متابولیک یکی از معضلات سلامتی در تمامی جوامع محسوب می شود. مداخلات ورزشی و مکمل از جمله رویکردهای بهبود وضعیت افراد مبتلا به سندروم متابولیک می­باشد. لذا هدف از پژوهش حاضر بررسی اثرات تمرین هوازی و مکمل دهی ویتامین D بر شاخص­های گلاسمیک در زنان یائسه مبتلا سندرم متابولیک بود.

مواد و روش­ها: این تحقیق از نوع نیمه تجربی، با طرح پیش آزمون-پس آزمون است. تعداد 46 نفر از بین زنان 50 تا 60 سال شهرستان کرمانشاه مبتلا به سندرم متابولیک داوطلب شدند و به 4 گروه شامل: تمرین هوازی + مکمل دهی ویتامین D (12 نفر)؛ تمرین هوازی (12 نفر)؛ مکمل دهی ویتامین D (12 نفر)؛ کنترل (12 نفر) تقسیم شدند. میزان قند خون ناشتا، انسولین پلاسما و شاخص مقاومت انسولین قبل و بعد از مداخله در چهار گروه اندازه گیری شد. در نهایت داده ها با استفاده از آزمون تحلیل کواریانس و آزمون تعقیبی بونفرونی با نرم افزار SPSS 24 در سطح معنی داری 05/0> P مورد تجزیه و تحلیل آماری قرار گرفت.

یافته­ها: نتایج تحقیق نشان می­دهد که پس از هشت هفته تمرین هوازی و مکمل­دهی ویتامین D ، تمرینات هوازی ، و مکمل­دهی ویتامین به طور معناداری باعث بهبود در میانگین سطح انسولین پلاسما، قند خون ناشتا و شاخص مقاومت انسولین شدند (05/0> P).

نتیجه گیری: بنظر می رسد انجام فعالیت های ورزشی و مکمل ویتامینD ، می تواند به عنوان یک روش درمانی مکمل در بهبود وضعیت سندرم متابولیک زنان یائسه مد نظر قرار گیرد.
کلیدواژه‌ها

عنوان مقاله English

The effect of 8 weeks of aerobic training and vitamin D supplementation on the glycemic index in postmenopausal women with metabolic syndrome

نویسندگان English

Parivash Najafi Nazar Abadi 1
Zaher Etemad 1
Rastegar Hoseini 2
Fatah Moradi 3
1 Department of Physical Education, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran
2 Department of Exercise Physiology, Faculty of Sport Sciences, Razi University, Kermanshah, Iran.
3 Department of Physical Education, Saghez Branch, Islamic Azad University, Saghez, Iran
چکیده English

Introduction: Metabolic syndrome is one of the health problems in all societies. Exercise interventions with supplements are among the approaches to improve the condition of patient with metabolic syndrome. Therefore, the aim of this study was to investigate the effects of aerobic training and vitamin D supplementation on glycemic parameters in postmenopausal women with metabolic syndrome.



Materials and Methods: This is a quasi-experimental study with a pre-test-post-test design. Forty-six women with metabolic syndrome aged 50-60 years were volunteered and divided into 4 groups, including: aerobic training with vitamin D supplementation (AT+Vit D, n=12); aerobic training (AT, n=12); Vitamin D supplementation (Vit D, n=12); and control (C, n=12). Aerobic training program performed for 8 weeks (3 sessions per week, 20 to 40 minutes of 60-75% of maximum heart rate). The supplemented groups consumed 50,000 IU of 25-hydroxyvitamin D supplement once a week for 8 weeks. Fasting blood glucose, plasma insulin, and insulin resistance index were measured before and after the intervention in four groups. Finally, the data were statistically analyzed using analysis of covariance and Bonferroni post hoc test with SPSS 24 software at a significant level of P <0.05.



Results: The results showed that eight weeks of AT+Vit D, AT, and Vit D significantly improved plasma insulin, fasting blood sugar, and insulin resistance index (<0.05). P).



Conclusion: It seems that exercise along with vitamin D supplementation can be considered as a therapeutic method to improve the metabolic syndrome in postmenopausal women.

کلیدواژه‌ها English

Aerobic training
Vitamin D
Insulin
Glucose
1. Mokhayeri Y, Riahi SM, Rahimzadeh S, Pourhoseingholi MA, Hashemi-Nazari SS. Metabolic syndrome prevalence in the Iranian adult’s general population and its trend: a systematic review and meta-analysis of observational studies. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2018;12(3):441-53.
2. Kachur S, Morera R, De Schutter A, Lavie CJ. Cardiovascular risk in patients with prehypertension and the metabolic syndrome. Current hypertension reports. 2018;20(2):15-23.
3. Deen JF, Krieger EV, Slee AE, Arslan A, Arterburn D, Stout KK, et al. Metabolic syndrome in adults with congenital heart disease. Journal of the American Heart Association. 2016;5(2):1132-40.
4. Huh JH, Kang DR, Jang J-Y, Shin J-H, Kim JY, Choi S, et al. Metabolic syndrome epidemic among Korean adults: Korean survey of Cardiometabolic Syndrome (2018). Atherosclerosis. 2018; 277:47-52.
5. Kränkel N, Bahls M, Van Craenenbroeck EM, Adams V, Serratosa L, Solberg EE, et al. Exercise training to reduce cardiovascular risk in patients with metabolic syndrome and type 2 diabetes mellitus: How does it work? European journal of preventive cardiology. 2019;26(7):701-8.
6. Yang Q, Zhu Z, Wang L, Xia H, Mao J, Wu J, et al. The protective effect of silk fibroin on high glucose induced insulin resistance in HepG2 cells. Environmental toxicology and pharmacology. 2019; 69:66-71.
7. Lundberg JO, Carlström M, Weitzberg E. Metabolic effects of dietary nitrate in health and disease. Cell metabolism. 2018;28(1):9-22.
8. De Sousa S. Metabolic syndrome, diet and exercise. Best Practice & research Clinical Obstetrics & Gynaecology. 2016; 37:140-51.
9. Barker T, Martins TB, Hill HR, Kjeldsberg CR, Dixon BM, Schneider ED, et al. Circulating pro-inflammatory cytokines are elevated and peak power output correlates with 25-hydroxyvitamin D in vitamin D insufficient adults. European journal of applied physiology. 2013;113(6):1523-34.
10. Zhang M, Gao Y, Tian L, Zheng L, Wang X, Liu W, et al. Association of serum 25-hydroxyvitamin D3 with adipokines and inflammatory marker in persons with prediabetes mellitus. Clinica Chimica Acta. 2017; 468:152-8.
11. Zhang Q, Wu Y, Lu Y, Fei X. Role of vitamin D in risk factors of patients with type 2 diabetes mellitus. Medicina Clínica (English Edition). 2020;154(5):151-6.
12. El Gendy HI, Sadik NA, Helmy MY, Rashed LA. Vitamin D receptor gene polymorphisms and 25 (OH) vitamin D: Lack of association to glycemic control and metabolic parameters in type 2 diabetic Egyptian patients. Journal of clinical & translational endocrinology. 2019; 15:25-9.
13. Chiu KC, Chu A, Go VLW, Saad MF. Hypovitaminosis D is associated with insulin resistance and β cell dysfunction. The American journal of clinical nutrition. 2004;79(5):820-5.
14. Jabri L, Rosenthal DM, Benton L, Lakhanpaul M. Complementary feeding practices and nutrient intakes of children aged 6–24 months from Bangladeshi background living in Tower Hamlets, East London: a feasibility study. Journal of Health, Population and Nutrition. 2020;39(1):1-15.
15. Hoseini R, Damirchi A, Babaei P. Vitamin D increases PPARγ expression and promotes beneficial effects of physical activity in metabolic syndrome. Nutrition. 2017; 36:54-9.
16. Malek M, Yousefi R, Safari S, Seyyedi SHS, Mottaghi A. Dietary intakes and biochemical parameters of morbidly obese patients prior to bariatric surgery. Obesity surgery. 2019;29(6):1816-22.
17. Amouzegar A, Azizi F, Ashrafivand S, Ahi Z, Saleh M, Mohaghegh S, et al. Prevalence of calcium and vitamin D deficiency and their association with feto-maternal outcomes in a sample of Iranian pregnant women. Human Antibodies. 2020;3(2):1-6.
18. Wimalawansa SJ. Associations of vitamin D with insulin resistance, obesity, type 2 diabetes, and metabolic syndrome. The Journal of steroid biochemistry and molecular biology. 2018; 175:177-89.
19. Prasad P, Kochhar A. Interplay of vitamin D and metabolic syndrome: a review. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2016;10(2):105-12.
20. Hoseini Z, Behpour N, Hoseini R. Co-treatment with Vitamin D Supplementation and Aerobic Training in Elderly Women with Vit D Deficiency and NAFLD: A Single-blind Controlled Trial. Hepatitis Monthly.20(2): 1-11.
21. Hoseini Z, Behpour N, Hoseini R. Vitamin D Supplementation Increases the Aerobic Training Effects on Anthropometric Indices in Elderly Women with Non-Alcoholic Fatty Liver Disease and Vitamin D Deficiency. Modern Care Journal. 2019;16(3):1-6.
22. Sharma A, Chan J, Trang T, Suarez MG. Prevalence of metabolic syndrome in older (50 years and older) vs younger (less than 50 years) patients with colorectal cancer diagnosed in a safety net hospital system. American Society of Clinical Oncology; 2016;2(2):12-18.
23. Gu Z, Li D, He H, Wang J, Hu X, Zhang P, et al. Body mass index, waist circumference, and waist-to-height ratio for prediction of multiple metabolic risk factors in Chinese elderly population. Scientific reports. 2018;8(1):385-90.
24. Jackson AS, Pollock ML. Generalized equations for predicting body density of men. British Journal of Nutrition. 1978;40(3):497-504.
25. Samuelson G. Global strategy on diet, physical activity and health. Taylor & Francis; 2004:2(1):12-20.
26. Heil DP. ACSM’s guidelines for exercise testing and prescription. Medicine and Science in Sports and Exercise. 2001;33(2):343-48.
27. Hoseini Z, Behpour N, Hoseini R. Co-treatment with Vitamin D Supplementation and Aerobic Training in Elderly Women with Vit D Deficiency and NAFLD: A Single-blind Controlled Trial. Hepat Mon. 2020;20(2);37-44.
28. Horii N, Hasegawa N, Fujie S, Uchida M, Iemitsu K, Inoue K, et al. Effect of combination of chlorella intake and aerobic exercise training on glycemic control in type 2 diabetic rats. Nutrition. 2019; 63:45-50.
29. Sahebi R, Rezayi M, Emadzadeh M, Salehi M, Tayefi M, Parizadeh SM, et al. The effects of vitamin D supplementation on indices of glycemic control in Iranian diabetics: a systematic review and meta-analysis. Complementary Therapies in Clinical Practice. 2019; 34:294-304.
30. Azarbayejani M, Abedi B, Piri M, Rasaie M. The Effects of a single session of combined aerobic and resistance exercise on leptin levels and insulin resistance index in sedentary men. Qom University of Medical Sciences Journal. 2012;6(1):46-54.
31. Bruce CR, Hawley JA. Improvements in insulin resistance with aerobic exercise training: a lipocentric approach. Medicine and science in sports and exercise. 2004;36(7):1196-201.
32. Glynn EL, Piner LW, Huffman KM, Slentz CA, Elliot-Penry L, AbouAssi H, et al. Impact of combined resistance and aerobic exercise training on branched-chain amino acid turnover, glycine metabolism and insulin sensitivity in overweight humans. Diabetologia. 2015;58(10):2324-35.
33. Maestro B, Dávila N, Carranza MC, Calle C. Identification of a Vitamin D response element in the human insulin receptor gene promoter. The Journal of steroid biochemistry and molecular biology. 2003;84(2-3):223-30.
34. Hangelbroek RW, Vaes AM, Boekschoten MV, Verdijk LB, Hooiveld GJ, van Loon LJ, et al. No effect of 25-hydroxyvitamin D supplementation on the skeletal muscle transcriptome in vitamin D deficient frail older adults. BMC geriatrics. 2019;19(1):151-159.
35. Ojuka EO. Role of calcium and AMP kinase in the regulation of mitochondrial biogenesis and GLUT4 levels in muscle. Proceedings of the Nutrition Society. 2004;63(2):275-8.
36. Cheng Q, Li Y, Boucher B, Leung P. A novel role for vitamin D: modulation of expression and function of the local renin–angiotensin system in mouse pancreatic islets. Diabetologia. 2011;54(8):2077-81.
37. Bi J, Watanabe H, Fujimura R, Nishida K, Nakamura R, Oshiro S, et al. A downstream molecule of 1, 25-dihydroxyvitamin D3, alpha-1-acid glycoprotein, protects against mouse model of renal fibrosis. Scientific reports. 2018;8(1):29-35.
38. Foroughi M, Maghsoudi Z, Ghiasvand R, Iraj B, Askari G. Effect of vitamin D supplementation on C-reactive protein in patients with nonalcoholic fatty liver. International journal of preventive medicine. 2014;5(8):969-77.