تغییرات سطوح سرمی آیریزین و لپتین به دنبال هشت هفته تمرین مقاومتی و مصرف مکمل اسید اورسولیک در مردان غیرفعال دارای اضافه وزن

نویسندگان
فاطمه قدیری
رامبد خواجه ای
آمنه برجسته یزدی
گروه فیزیولوژی ورزش، واحد نیشابور، دانشگاه آزاد اسلامی، نیشابور، ایران
چکیده
مقدمه

اسیداورسولیک یک ترکیب تری‌ترپنوئید لیپوفیلیک بوده که از گیاهان استخراج می‌شود. اسیداورسولیک ممکن است اثر تمرینات مقاومتی را در انسان تقویت کند. از این­رو، پژوهش حاضر با هدف بررسی تغییرات سطح سرمی آیریزین و لپتین در پاسخ به هشت هفته تمرین مقاومتی و مصرف مکمل اسیداورسولیک در مردان غیرفعال دارای اضافه وزن انجام شد.

مواد و روش‌­ها

در این پژوهش، 36 مرد غیرفعال دارای اضافه­وزنِ داوطلب انتخاب و به‌طور تصادفی به سه گروه تمرین مقاومتی+اسیداورسولیک (12نفر)، تمرین مقاومتی+دارونما (12نفر) و اسیداورسولیک (10نفر) تقسیم شدند. تمرینات مقاومتی به مدت 8 هفته و با تواتر سه جلسه در هفته شامل چهار حرکت بالاتنه و چهار حرکت پایین­تنه بود که با شدت 85-70 درصد یـک تکـرار بیشینه انجام شد. آزمودنی­های گروه تجربی با هر وعده غذایی 150 میلی­گرم اسیداورسولیک و یا دارونما مصرف کردند. تحلیل آماری داده­ها با کمک آزمون آماری آنالیز واریانس یک­طرفه و با استفاده از نرم‌افزار SPSS صورت گرفت.

یافته‌­ها

آیریزین به‌طور معنی­داری در هر سه گروه تمرین+اسیداورسولیک (8/27%)، تمرین+دارونما (7/9%) و مکمل (4%) افزایش یافت. از طرفی، سطح سرمی لپتین به طور معنی­داری در هر سه گروه کاهش یافت (به ترتیب 7/38، 7/18 و 7/4 درصد). تغییرات سرمی آیریزین و لپتین بین گروه­های تمرین+اسیداورسولیک با تمرین+دارونما، تمرین+اسیداورسولیک با اسیداورسولیک به تنهایی و همچنین بین گروه­های تمرین+دارونما با اسیداورسولیک تفاوت معنی­داری داشت.

نتیجه­‌گیری

نتایج نشان داد مصرف اسیداورسولیک اثر تمرینات مقاومتی را فزونی بخشید، لذا از برنامه تمرین مقاومتی و مصرف مکمل اسیداورسولیک می‌توان در تدوین استراتژی مداخله سبک زندگی کارآمد در افراد غیرفعال دارای اضافه وزن استفاده نمود.
کلیدواژه‌ها
تمرین مقاومتی
آیریزین
لپتین
اسیداورسولیک

عنوان مقاله English

Changes of serum levels of Irisin and leptin following eight weeks of resistance training and Ursolic acid supplementation in inactive overweight male

نویسندگان English

Fatemeh Ghadiri
Rambod Khajei
Ameneh Barjasteh Yazdi
Department of Exercise Physiology, Neyshabur Branch, Islamic Azad Universit, Neyshabur, Iran
چکیده English

Introduction

Ursolic acid (UA) is a lipophilic triterpenoid extracted from plants. UA may augment the effect of resistance training (RT) in humans. Therefore، the purpose of this study was to investigate the effects of eight weeks of RT and UA supplementation on serum level of Irisin and leptin in sedentary overweight men.

Materials and Methods

A total of 34 inactive overweight men voluntarily participated in، and randomly assigned into three groups: RT + UA (n=12), RT + placebo (n=12), and UA (n=10). RT program performed eight weeks، three sessions per week and included four upper body and four lower-body movements performed at 70-85% one-repetition maximum. Participants consumed 150 mg of UA or placebo (Flavored Maltodextrin) along with every meal. Data were analyzed using one-way analysis of variance (one-way ANOVA) test by SPSS (p< 0.05).

Results

Irisin was significantly increased in all three RT + UA (27.8%), RT + placebo (9.8%) and UA (4%) groups. On the other hand، the serum level of leptin was significantly decreased in all groups (38.7%, 18.7%, and 4.7%, respectively). Changes of both serum Irisin and leptin were significantly different between the RT + UA and RT + placebo, RT + UA and placebo, and RT + placebo and placebo groups.

Conclusion

The results showed that UA enhance the impact of RT. Accordingly, the RT program and UA supplementation can be used to develop an effective lifestyle intervention strategy in inactive, overweight people.

کلیدواژه‌ها English

resistance training
Irisin
leptin
Ursolic Acid
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