تاثیر یک دوره تمرینات مقاومتی همراه با مصرف عصاره گیاه بادرنجبویه بر حافظه کاری، مرجع و میزان رسوب آمیلوییدبتا در هیپوکامپ رت‌های نر آلزایمری القا‌شده

نویسندگان
مهناز نوردی 1
رامین شعبانی 2
شهرام غلامرضایی دارسرا 3
1 دانشجوی دکترای فیزیولوژی ورزشی، گروه تربیت بدنی و علوم ورزشی، واحد رشت، دانشگاه آزاد اسلامی، رشت، ایران
2 استاد فیزیولوژی ورزشی، گروه تربیت بدنی و علوم ورزشی، واحد رشت، دانشگاه آزاد اسلامی، رشت، ایران
3 استادیار فیزیولوژی ورزشی، گروه تربیت بدنی و علوم ورزشی، واحد رشت، دانشگاه آزاد اسلامی، رشت، ایران
چکیده
مقدمه: بیماری آلزایمر یک اختلال پیشرونده وغیرقابل برگشت است که نه تنها بیماران را تحت‌تاثیر قرارمی‌دهد بلکه عواقب شدیدی بر زندگی روزمره، روابط اجتماعی و سلامت روان مراقبین نیز دارد. بنابراین، هدف از پژوهش حاضر تاثیر تمرینات مقاومتی همراه با مصرف عصاره گیاه بادرنجبویه بر حافظه‌ کاری، مرجع و میزان رسوب آمیلوییدبتا در هیپوکامپ رت‌های نر آلزایمری القا‌شده‌بود.

روش: در مطالعه تجربی حاضر، تعداد 32 سر رت نر بالغ به‌طور تصادفی به چهار گروه مختلف شامل گروه کنترل، گروه تمرینات مقاومتی، گروه تمرینات مقاومتی به همراه عصاره و گروه فقط عصاره تقسیم‌بندی شدند. برای ایجاد مدل آلزایمری، از تزریق آمیلوئید بتا 42-1 به درون هیپوکامپ استفاده‌شد. تمرینات مقاومتی طی 8 هفته، به‌صورت سه جلسه در هفته برگزارشد. به منظور ارزیابی حافظه‌ کاری، از آزمون ماز هشت بازویی بهره‌گرفته‌شد و برای اندازه‌گیری آمیلوئید بتا از روش الایزا استفاده‌شد. آنالیز داده‌ها با استفاده از آزمون آنالیز واریانس یک‌‌طرفه صورت‌گرفت.

یافته‎ها: یافته‌ها حاکی از آن است که پس از هشت هفته تمرین مقاومتی به همراه مصرف مکمل بادرنجبویه، عملکرد حافظه کاری در گروه‌های مداخله نسبت به گروه کنترل به‌طور معنی‌داری افزایش‌یافت. همچنین، در گروه‌های تمرینات مقاومتی، تمرینات مقاومتی به همراه عصاره و عصاره، میزان رسوب آمیلوئید بتا نسبت به گروه کنترل کاهش معنی‌داری را نشان‌دادند (0/05 p <).

نتیجه‎گیری: به نظر می‌رسد که تمرینات مقاومتی و مصرف عصاره بادرنجبویه می‌توانند منجربه بهبود عملکرد حافظه کاری و کاهش رسوب آمیلوئید بتا در بافت هیپوکامپ رت‌های نر مبتلا به آلزایمر شوند.
کلیدواژه‌ها
مرینات مقاومتی
باد رنجبویه
آلزایمر
حافظه کاری
آمیلوئید بتا

عنوان مقاله English

The Effect of Resistance Training with Melissa Officinalis Extract on Working Memory, Reference and Amyloid-Beta Deposition in the Hippocampus of Male Alzheimer's Induced Rats

نویسندگان English

mahnaz navardi 1
ramin shabani 2
shahram gholamrezaii darsara 3
1 PhD candidate in Exercise Physiology, Department of Physical Education and Sport Sciences, Rasht Branch, Islamic Azad University, Rasht, Iran
2 Professor in Exercise Physiology, Department of Physical Education and Sport Sciences, Rasht Branch, Islamic Azad University, Rasht, Iran
3 Assistant Professor in Exercise Physiology, Department of Physical Education and Sport Sciences, Rasht Branch, Islamic Azad University, Rasht, Iran
چکیده English

Introduction: Alzheimer's disease is a progressive neurodegenerative disorder that leads to the gradual destruction of brain tissue and significant disturbances in cognitive function. So far, no definitive treatment for Alzheimer's disease has been identified, so this study aimed to investigate the effect of aerobic exercise along with passion fruit extract on memory and the amount of amyloid-beta deposition in the hippocampal tissue of Alzheimer's male rats.

Methods: In this experimental study, 32 adult male rats were randomly divided into four groups: control, aerobic exercise group, aerobic exercise group with extract, and extract only groups model. To create an Alzheimer's diseases model, amyloid beta 42-1 was injected into the hippocampus. Aerobic exercises were conducted three times a week for 8 weeks. In order to evaluate working memory, the eight-arm maze test was used, and the ELISA method was used to measure beta-amyloid content. Data analysis was done using one-way analysis of variance.

Results: The findings indicate that after eight weeks of aerobic training along with the consumption of Bad Rangebuieh supplement, working memory performance in the intervention groups increased significantly compared with the control group. In addition, in the groups of aerobic exercises, aerobic exercises along with extract and extract showed a significant decrease in amyloid beta deposition compared with the control group (P>0.05).

Conclusion: Aerobic exercises and passion fruit extract can improve working memory performance and reduce beta-amyloid deposition in the hippocampal tissue of male Alzheimer's rats.

کلیدواژه‌ها English

resistance training
Bad Rangboeh
Alzheimer's
Working Memory
Beta Amyloid
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