The role of personality psychopathology profiles (PSY-5) based on MMPI-3 in cognitive deficits in patients with multiple sclerosis (MS)

Authors
1 PhD student in health Psychology, Department of Psychology, Gorgan Branch, Islamic Azad University, Gorgan, Iran.
2 Assistant Professor, Department of Psychology, Rodhen Branch, Islamic Azad University, Rodhen, Iran.
3 Associate Professor, Department of Psychology, Roudehen Branch, Islamic Azad University, Roudehen, Iran.
4 . PhD student in health Psychology, Department of Psychology, Roudehen Branch, Islamic Azad University, Roudehen, Iran
Abstract
Introduction: Understanding the relationship between personality and multiple sclerosis (MS) is crucial for optimizing disease treatment methods and identifying the impact of these characteristics on disease evolution. Accordingly, this study aimed to investigate the role of personality psychopathology profiles (PSY-5) based on MMPI-3 in cognitive deficits in patients with MS.

Methods and Materials: The present study was a correlational study. The statistical population included all patients with MS in Mashhad city, who had visited specialized neurology clinics and Mashhad MS patients' support association between October and December 2024, and 270 of them were selected by convenience sampling method. The research tools included the Minnesota multidimensional personality questionnaire - third edition (MMPI-3) and Montreal Cognitive Assessment (MoCA) Version 8.2. For data analysis, Pearson correlation method and multiple regression analysis were used in SPSS version 26 statistical software.

Results: The results of the present study showed that the highest correlation was observed between disconstraintand the psychoticism and the lowest correlation was observed between disconstraintand and the negative emotionality/neuroticism (p<0.01). The research findings also showed that the profiles of negative emotionality/neuroticism, introversion/low positive emotionality and psychoticism play a role in cognitive deficits in MS patients, and these components collectively predict 28% of the variance in cognitive deficits in MS (p<0.01). In addition, it was found that a one-unit increase in each of these constructs resulted in a 0.28, 0.23, and 0.18 unit increase in cognitive deficit scores, respectively.

Conclusions: Based on this and considering the relationship of personality dimensions and cognitive deficits in MS patients, it is suggested that educational and therapeutic programs be designed and implemented to promote and improve positive personality capabilities and modify negative personality dimensions through mental health service organizations, including counseling and treatment centers in education, hospitals, and universities, in order to reduce and modify cognitive deficits in these patients.




Keywords